Oxsoralen-Ultra®
Indication
Oxsoralen-Ultra® (Methoxsalen Capsules, USP, 10mg) is used for the treatment of severe psoriasis and is used along with ultraviolet light radiation. Studies show that UVA therapy with Oxsoralen-Ultra® effectively clears or improves severe, recalcitrant, disabling psoriasis in 84% of the patients who undergo this therapy. Studies further show that it can lead to extended remissions lasting from months to years.
Product Description
Oxsoralen-Ultra® is composed of methoxsalen, a naturally occurring photoactive substance found in the seeds of the Ammi majus plant and in the roots of Heracleum Candicans. It belongs to a group of compounds known as psoralens. Psoralens are usually taken orally. Oxsoralen-Ultra® comes in a liquid-filled soft gelatin capsule form.
Studies show that UVA therapy with Oxsoralen-Ultra® effectively clears or improves severe, recalcitrant, disabling psoriasis in 84% of the patients who undergo this therapy. Studies further show that it can lead to extended remissions lasting from months to years.
Product Availability
- United States
- Canada
- Australia
- New Zealand
- Brazil
- Mexico
Important Safety Information
CAUTION: METHOXSALEN IS A POTENT DRUG. READ ENTIRE BROCHURE PRIOR TO PRESCRIBING OR DISPENSING THIS MEDICATION.
Methoxsalen with UV radiation should be used only by physicians who have special competence in the diagnosis and treatment of psoriasis and who have special training and experience in photochemotherapy. The use of Psoralen and ultraviolet radiation therapy should be under constant supervision of such a physician. For the treatment of patients with psoriasis, photochemotherapy should be restricted to patients with severe, recalcitrant, disabling psoriasis which is not adequately responsive to other forms of therapy, and only when the diagnosis is certain. Because of the possibilities of ocular damage, aging of the skin, and skin cancer (including melanoma), the patient should be fully informed by the physician of the risks inherent in this therapy.
CAUTION: Oxsoralen-Ultra® (Methoxsalen Soft Gelatin Capsules) should not be used interchangeably with regular Oxsoralen® or 8-MOP® (Methoxsalen Hard Gelatin Capsules). This new dosage form of methoxsalen exhibits significantly greater bioavailability and earlier photosensitization onset time than previous methoxsalen dosage forms. Patients should be treated in accordance with the dosimetry specifically recommended for this product. The minimum phototoxic dose (MPD) and phototoxic peak time after drug administration prior to onset of photochemotherapy with this dosage form should be determined.